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August 3, 2020
November 25, 2019
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Recombinant Protein Technology

The technology to program bacterial cells into producing human proteins has been around for decades and has revolutionized the way pharmaceutical companies are able to produce injectable proteins like human insulin, for example. The human gene for insulin has been inserted into a common strain of bacteria, cultured in huge tanks to produce insulin, which is then collected, purified and used to treat diabetes without getting many of the allergies associated with insulins derived from pigs or cattle (as was the case over 30 years ago).

Plants are more ideally suited to producing recombinant human Intrinsic Factor (rH-IF) because, unlike animal cells, plants don't have B12-binding proteins to interfere with the purity of IF produced by this technology. The rH-IF has been tested in humans and shown to work in a published pilot clinical study.

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Who Wrote This
Jonathan Bortz MD
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Jonathan’s background as a practicing diabetes specialist for 15 years and 17-year career developing nutritional prescriptive products for the pharmaceutical industry has contributed to his ability to understand nutrients, how they work and why they are important.

Over the years he has acquired broad and in-depth knowledge in minerals, essential fatty acids and other nutrients, but has special expertise in Vitamin B12 and choline metabolism. He is often asked to speak at national and international venues to articulate why B12, folate and choline are so important to gene function, brain development, liver and cardiovascular health. He applies pharmaceutical standards to nutrient science and has developed a unique ability to translate complicated concepts into simple promotional messages that resonate with practitioners and consumers. He has developed dozens of innovative nutritional products, of which many are category leaders in the US. Jonathan obtained his medical degree from the University of the Witwatersrand Medical School in South Africa and did his fellowship in Endocrinology at Washington University in St. Louis, MO.

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