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August 3, 2020
November 25, 2019
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What's IF?

Why such a funny name? Well, there's a story. About 150 years ago, a strange anemia was described and was associated with thinning (or atrophy) of the stomach lining. It was called Pernicious Anemia. These patients often didn't survive for more than 3 years after diagnosis, but a life saving treatment diet of raw liver which contained an 'Extrinsic Factor' earned a Nobel Prize in 1934.

A scientist then figured out that the 'Extrinsic Factor' (B12) had to be working with an 'Intrinsic Factor' made in the stomach to cure Pernicious anemia.

And so it was. Intrinsic Factor, (otherwise known as IF) is a protein made in the stomach that is essential for ensuring the natural absorption of vitamin B12.

IF is needed to bind to B12, thereby protecting it from being damaged by acid and enzymes in the GI tract and taking it down the full length of the small intestine where special absorption receptors recognize the B12-IF complex, and only the complex, not B12 by itself, and not IF by itself.

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Who Wrote This
Jonathan Bortz MD
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Jonathan’s background as a practicing diabetes specialist for 15 years and 17-year career developing nutritional prescriptive products for the pharmaceutical industry has contributed to his ability to understand nutrients, how they work and why they are important.

Over the years he has acquired broad and in-depth knowledge in minerals, essential fatty acids and other nutrients, but has special expertise in Vitamin B12 and choline metabolism. He is often asked to speak at national and international venues to articulate why B12, folate and choline are so important to gene function, brain development, liver and cardiovascular health. He applies pharmaceutical standards to nutrient science and has developed a unique ability to translate complicated concepts into simple promotional messages that resonate with practitioners and consumers. He has developed dozens of innovative nutritional products, of which many are category leaders in the US. Jonathan obtained his medical degree from the University of the Witwatersrand Medical School in South Africa and did his fellowship in Endocrinology at Washington University in St. Louis, MO.

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