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1 Data on File. Subset Analysis of 6 subjects with IF deficiency from Hvas (2006) cohort. (Xeragenx LLC.)

2 Bor MV, et al. Holo-Transcobalamin Concentration and Transcobalamin Saturation Reflect Recent Vitamin B12 Absorption Better than Does Serum Vitamin B12. Clinical Chemistry. 2004; 50(6):1043-1049.

3 Carmel R. The Disappearance of Cobalamin Absorption Testing: A Critical Diagnostic Loss. J Nutr. 2007; 137:2481-2484.

4 Allen, R. H., & Stabler, S. P. (2008). Identification and quantification of cobalamin and cobalamin analogues in human feces. American Journal of Clinical Nutrition , 87, 1324-1335. .

5 Degnan, P. H., Barry, N. A., Mok, K. C., Taga, M. E., & Goodman, A. L. (2014). Human Gut Microbes Use Multiple Transporters to Distinguish Vitamin B12 Analogs and Compete in the Gut. Cell Host & Microbe , 15.

6 Zaidel, O., et al; Uninvited Guests: The Impact of Small Intestinal Bacterial Overgrowth on Nutritional Status. (2003) GASTROENTEROLOGY • JULY 2003

7 King CE, Toskes PP. Small intestine bacterial overgrowth. Gastroenterology, 1979; 76: 1035-1055.32.

8 Stabler, S. P., Brass, E. P., Marcell, P. D., & Allen, R. H. (1991). Inhibition of Cobalamin-dependent Enzymes by Cobalamin Analaogues in Rats. Journal of Clincial Investigation , 87, 1422-1430.

9 McCaddon, A., Hudson, P., Abrahamsson, L., Olofsson, H., & Regland, B. (2001). Analogues, Ageing and Aberrant Assimilation of Vitamin B12 in Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders , 12, 133-137..

10 Carmel, R., Karnaze, D. S., & Weiner, J. M. (1998). Neurologic abnormalities in cobalamin deficiency are associated with higher cobalamin "analogue" values than are hematologic abnormalities. Journal of Laboratory and Clinical Medicine .

11 Arendt, J. F., et al; (2013). Elevated Plasma Vitamin B12 Levels as aMarker for Cancer: A Population-Based Cohort Study.Journal of NationalCancer Institute, 105(23), 1799-1805

12 Bor MV., et al; Daily intake of 4 to 7 microg dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population. (2010) Am J Clin Nutr.91(3):571-7.

13 Bor, MV., et al; A daily intake of approximately 6 microg vitaminB-12 appears to saturate all the vitamin B-12-related variables in Danish postmenopausal women. (2006) Am J Clin Nutr. Jan;83(1):52-8. 

14 Personal communication with Ebba Nexø, October 24, 2012

15 Heyssel, R., & al, e. (1966). Vitamin B12 Turnover in Man. Am. Journal of Clinical Nutr., 18, 176-184.

16 Hvas, A., et alThe effect of recombinanthuman intrinsic factor on the uptake of vitamin B12 in patients with evidentvitamin B12 deficiency. (2006) Haematologica. Jun;91(6):805-8.