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B12
Intrinsic Factor
Supplements
Drug Delivery
Diagnostic

Featured

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March 9, 2022
/
1 Minute Read
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Complexity Rating

What's Your SAT Score?

It's Not What You Think - It's HOW You Think!

X Fact - All Categories

B Vitamins
B12
B6
Choline
Clinical
Drug Delivery
Folate
History
Intrinsic Factor
Methylation
Omega-3 Fatty Acids
Personalized Nutrition
SNPs
Single Carbon
Testing for B12

X Fact Top Picks

February 21, 2021

Is There a Better Blood Test for B12 Deficiency Other Than a B12 Level?

The MMA Test Teaches a Lot About Why B12 is So Important for Energy

Read
February 3, 2021

Higher Omega-3 Index Levels Associated with Lower Risk for Death from COVID-19

First Study to Find a Link

Read
January 18, 2021

Intrinsically Motivated

B12 Absorption Pathway and Players Offer Unique Opportunities for Drug Delivery

Read
December 29, 2020

Excess Vitamin B12 Doubles Lung Cancer Risk

Anything Above 55mcg B12 is Considered Excess

Read

Contributors

Jonathan Bortz MD

Steven H. Zeisel MD PhD

William S. Harris PhD FAHA

Robert P. Doyle PhD

Kevin C. Klatt PhD RD

X Fact All Posts

March 9, 2022
What's Your SAT Score?

It's Not What You Think - It's HOW You Think!

read
March 6, 2022
The Cornell 7-Year Study

Prenatal Choline Improves Cognitive Attention in Young School Children

read
January 10, 2022
Choline: Rectifying An "In-Adequate" Intake (IAI) for Pregnancy

Superior Sustained Attention in Children of Mothers Taking 2X the Recommended AI for Choline

read
July 7, 2021
uMMA - 'Catch-22' or Catch-all?

uMMA is Especially Useful When Blood B12 Levels are in the Low Normal Range

read
June 14, 2021
Alzheimer's, B Vitamins and Omega-3 Fatty Acids

Team Brain Power: B12, Folate, Omega-3s and B6

read
May 19, 2021
The Target Omega-3 Index Number is...

Red Blood Cell Membrane Omega-3 Content Associated with Better Health Outcomes

read
May 9, 2021
Leveling the Playing Field with Choline.

Helping Address Disparities in Healthcare

read
April 23, 2021
What is the Omega-3 Index and Why Does it Matter?

Higher Red Blood Cell Omega-3 Levels Associated with Improved All-Cause Mortality

read
April 18, 2021
The Connection Between Dietary Protein, Stomach Acid and Vitamin B12

Extracting B12 from Food depends on Protein Sensing and Gastric Acid Production

read
March 15, 2021
MIT Scientists Discover a Key Insight into Alzheimer's Disease

THE Major Genetic Risk Factor Mitigated by Choline Supplementation

read
February 27, 2021
Why Doctors Should be Ordering uMMA Tests for B12 Deficiency

Urinary MMA is a Superior Test For Detecting B12 Deficiency, and for Good Reason.

read
February 21, 2021
Is There a Better Blood Test for B12 Deficiency Other Than a B12 Level?

The MMA Test Teaches a Lot About Why B12 is So Important for Energy

read
February 14, 2021
Are we getting enough choline in our diet?

Over 90% of Adult Americans are Choline Deficient

read
February 3, 2021
Higher Omega-3 Index Levels Associated with Lower Risk for Death from COVID-19

First Study to Find a Link

read
February 1, 2021
When Alzheimer's Disease Could Be Diagnosed Only After Death

The Discovery That Launched the Search for Treatment

read
January 18, 2021
Small or Big

Versatile Therapeutic or Diagnostic Delivery Vehicle

read
January 18, 2021
Motivated Conjugates

The B12 Bridge That Opens New Frontiers

read
January 18, 2021
Intrinsically Motivated

B12 Absorption Pathway and Players Offer Unique Opportunities for Drug Delivery

read
January 8, 2021
Is There a Relationship Between Choline and DHA?

Fetal Brain Development Needs DHA and DHA Needs Choline to Get There

read
December 29, 2020
Excess Vitamin B12 Doubles Lung Cancer Risk

Anything Above 55mcg B12 is Considered Excess

read
December 17, 2020
Does Mom Supply Her Baby with Vitamin B12 at Her Own Expense?

Prenatal B12 Sufficiency Doesn't Protect Mom From B12 Deficiency

read
December 9, 2020
Phosphatidylcholine: Novel Frontiers

A Mechanism to Explain How Phospholipids Containing Choline Modulate Gene Expresssion

read
December 6, 2020
Was Mary Todd Lincoln a Victim of the Forgotten Disease That Hadn't Been Described Yet?

Pernicious Anemia Could Explain It All

read
November 26, 2020
Higher Fracture Risk for Vegans and Vegetarians

Does B12 deficiency Play a Role?

read
November 19, 2020
Prenatal Vitamins - the House that Folate Built

Folate AND Vitamin B12 are Important Supplements Before and Early in Pregnancy

read
November 12, 2020
Phosphatidylcholine: A Key Source of DHA

The Gene That Controls the Synthesis of Phosphatidylcholine via the PEMT Pathway Controls DHA Levels in the Body

read
November 6, 2020
I Have to Eat What Now? Half-a-Pound of Liver? Every Day? Seriously??

How Choosing the Right Diet for the Wrong Reason Led to Solving the Mystery Behind Pernicious Anemia

read
October 28, 2020
How Much of Mom's Folate Supplement is Available to Her Nursing Infant?

Breast-Milk Folate is the Primary Source of Folate for Breastfed Infants

read
October 25, 2020
Is Folic Acid Metabolized Differently in Women at Different Stages in the Child Bearing Years?

Conversion of Folic Acid to Metabolically Active Folate

read
October 19, 2020
What’s in a name..? The case of the missing B vitamins.

"That By Which We Call a Rose. By Any Other Name Would Smell As Sweet." William Shakespeare, Romeo & Juliet

read
October 15, 2020
Is the Need for Taking Prenatal Folate Only Important in Early Pregnancy?

Insights into Folate Requirements Throughout Pregnancy and Lactation

read
October 12, 2020
Choline, B-vitamins and Autism

A Mouse Model of a Common Form of Autism Shows a Benefit of Supplementing Choline

read
October 9, 2020
How a Crude Clinical Experiment Exposed the Elegance of Vitamin B12 Absorption

The Ingenious Scientific Protocol That Would Never Be Approved Today

read
October 6, 2020
Numbness and Tingling Symptoms in Hypothyroidism May Be Due To Vitamin B12 Deficiency

Doctors Should Be Screening for Vitamin B12 Deficiency in Hypothyroid Patients

read
October 2, 2020
The First Ever Scientific Publication

The 17th Century Equivalent of the Internet for Scientists

read
September 30, 2020
Most Americans Are Not Consuming Enough Choline in Their Diet

Only 8% of Pregnant Women are Meeting Choline Recommendations

read
September 25, 2020
Does a Normal Vitamin B12 Level Exclude the Diagnosis of Pernicious Anemia?

The Role of Antibodies in Giving Spuriously High B12 Measurements

read
September 22, 2020
Is There a Difference in the Absorption of Folic Acid and Folate?

Folic Acid and Folate Are Not Interchangeable Terms for the Same Vitamin

read
September 18, 2020
Choline, B12 and Folate are Joined at the Hip, and the Hip is called Methionine

The Interdependence of Single Carbon Nutrients and What an Elevated Homocysteine Level Tells Us

read
September 14, 2020
Can Pregnant Women Make Enough Choline to Support Their Baby and Themselves?

Choline Production is Revved Up in Last Trimester

read
September 10, 2020
What Exactly are the Auto-Antibodies of the Autoimmune Disease, Pernicious Anemia?

The Antibodies That Destroy Intrinsic Factor and the Cells that Make it in the Stomach.

read
September 8, 2020
Have You Taken Your Orizanins Today?

The 1910 Discovery That Was Lost in Translation

read
September 7, 2020
A Connection Between Vitamin B12 and Iron?

The Molding of Many Twentieth Centuries Leaders

read
September 4, 2020
Why Do Our Genes Cause Us To Be Metabolically Unique?

Small Gene Variations from Misspellings are Frequent and May Have a Big Effect on Metabolic Processes

read
September 3, 2020
Worried About Cognitive Decline and Is There Anything to Do About It?

Blood Homocysteine is a Modifiable Risk Factor for Alzheimer's Disease

read
September 1, 2020
Is There a Difference Between "Personalized" and "Precision" Nutrition?

Thousands of Pathways Exist to Metabolize Nutrients, and People Have Very Different Efficiencies in These Pathways

read
September 1, 2020
Choline, "The Mother-Substance-of-All"

Choline Identified as Important Component in Human Brain in 1865

read
August 28, 2020
Vitamin B12 Deficiency is Very Common in Thyroid Disease

Atrophic Gastritis and Pernicious Anemia is Often Associated with Thyroid Disease

read
August 26, 2020
Are Older People More Likely to be Vitamin B12 Deficient?

Vitamin B12 Declines with Age Due to Gastric Dysfunction and is NOT a Normal Consequence of Aging

read
August 24, 2020
Vitamin B12 Turns Competitors into Colleagues

Competing Scientists Pool Their Resources to Crack the Vitamin B12 Structure

read
August 21, 2020
Measuring MMA Levels can Detect Vitamin B12 Deficiency Even When a Vitamin B12 Blood Test is Normal

MMA Test is More Sensitive at Diagnosing Mild or Moderate B12 Deficiency than Vitamin B12 Levels

read
August 18, 2020
Is High Vitamin B12 Status a Cause of Lung Cancer?

High Dose Vitamin B12 Doses May Increase Risk for Lung Cancer

read
August 13, 2020
What Does the American Civil War Have to Do with Choline?

Choline is Named After the Body Fluid in which it Was First Characterized- Bile

read
August 11, 2020
Should Doctors be Testing Vitamin B12 Status in Diabetics?

Vitamin B12 Deficiency is Very Common in Diabetics and Diagnosis and Treatment Could Bring Huge Benefits

read
August 10, 2020
Why Phospholipids are So Important and Solves the Oil Doesn't Mix with Water Problem?

Phospholipids are the Molecules that Carry and Transport Fats in the Body

read
August 6, 2020
Nobel Prize for Chemistry Awarded for Discovering the Structure of Vitamin B12

Nobel Prize Awarded for Characterizing Vitamin B12

read
August 5, 2020
Are Overweight People More Likely to Have Low Vitamin B12 Levels?

Obesity is Associated with Low Vitamin B12 Status

read
August 3, 2020
Vegans and Vegetarians are More Vulnerable to Develop Vitamin B12 Deficiency

There are many more people who don’t have enough B12 than we thought.

read
August 3, 2020
A More Accurate Way of Measuring Vitamin B12 Status than a B12 Blood Level

MMA Measurement is a More Accurate Way to Evaluate Vitamin B12 Status

read
July 31, 2020
Can You Spot a Person with Vitamin B12 Deficiency at the Airport?

read
July 29, 2020
Is Measuring Blood Vitamin B12 Levels the Best Way to Test for Vitamin B12 Deficiency?

The Most Common Test for B12 Misses Deficiency Most Commonly

read
July 24, 2020
How a Sandwich Spread Helped Scientists Discover the Cause & Treatment of Pernicious Anemia

read
July 23, 2020
Can Gene Mutations Be Inherited and What Does This Have to Do With Nutrition?

read
July 20, 2020
Why Demand for Choline Is So High in Pregnancy

read
July 15, 2020
How Scientists Discovered Intrinsic Factor and Its Vital Role in Vitamin B12 Absorption

read
July 14, 2020
What Are SNPs (Pronounced SNIPS) and Why Are They Important?

read
July 13, 2020
We Need to Understand the Basics of Genes to Understand Nutrition

read
July 10, 2020
Does Gastric Bypass Surgery Cause Lifelong Vitamin B12 Deficiency?

read
July 9, 2020
Why Vitamin B12 Deficiency Is Common in Vegans, Vegetarians and Ovo-Vegetarians

read
July 6, 2020
How Scientists Discovered That The Mysterious 'Extrinsic Factor' in Liver was Vitamin B12

read
July 3, 2020
Why Vitamin B12 was Called 'Extrinsic Factor' by the Scientist Who Predicted That it Must Exist

read
June 30, 2020
Do You Know That What You Eat Can Control Whether Your Genes Do Their Job Properly?

read
June 29, 2020
Pernicious Anemia is the Name of the Anemia Caused by Severe Vitamin B12 Deficiency

read
June 26, 2020
How does a Big Molecule Like Vitamin B12 Get Absorbed from the Intestine?

read
June 25, 2020
Vitamin B12's Size Makes it Very Vulnerable to Being Destroyed by Gastric Acid

read
June 24, 2020
What Does the Color of Blood Have in Common With Vitamin B12?

read
June 23, 2020
Are There Nutrients Other than Choline That Contain Single Carbon Methyl Groups?

read
June 22, 2020
Why Its Important to Know the Molecular Structure of Choline

read
June 22, 2020
What on Earth is a Methyl Group and Why do We Care?

read
June 21, 2020
B vitamins Play a Key Role in Supplying Single Carbon Methyl Groups for Gene Expression

read
June 19, 2020
Vitamin B12 is named after the rare earth metal at its center

read
June 18, 2020
How Spinach Came to Give Vitamin B9 Its Name - Folic Acid

read
June 18, 2020
Is There a Difference between Folate and Folic Acid?

read
June 17, 2020
Companies Use Bacteria to Produce Vitamin B12 as the Most Efficient Way to Produce Industrial Quantities for Human Use

read
June 16, 2020
B12 is the Biggest and Most Complex Vitamin by Far

read

recent X Facts

February 21, 2021

Is There a Better Blood Test for B12 Deficiency Other Than a B12 Level?

The MMA Test Teaches a Lot About Why B12 is So Important for Energy

February 3, 2021

Higher Omega-3 Index Levels Associated with Lower Risk for Death from COVID-19

First Study to Find a Link

January 18, 2021

Small or Big

Versatile Therapeutic or Diagnostic Delivery Vehicle

January 18, 2021

Motivated Conjugates

The B12 Bridge That Opens New Frontiers

Recent Glossary Words

Executive Function
Predetermined Response
Adequate Intake (AI)
Brain Atrophy
Adipose

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Xeragenx LLC is a biotechnology company specializing in the development, and supply of plant-derived recombinant human Intrinsic Factor (rh-IF) for multiple applications, including use in foods, beverages and dietary supplements.  All information on this website is provided for informational and educational purposes only, and is intended solely as a business-to-business (B2B) communication. This information is not intended for use by consumers and should not be construed as medical advice.

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