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X Fact
June 17, 2020
20 Second Read
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Companies Use Bacteria to Produce Vitamin B12 as the Most Efficient Way to Produce Industrial Quantities for Human Use

Chemical synthesis of B12 is tedious and requires about 70 reactions. Microbes like bacteria can produce B12 more efficiently from scratch, or by using fragments via a 'salvage' pathway (analogous to assembling a car from junkyard parts). B12 manufacturers produce the world's supply in massive fermentation tanks containing B12 producing bacteria and only a handful are capable of doing so at large scale in these microbial bioreactors

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Who Wrote This X Fact
Jonathan Bortz MD
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Jonathan’s background as a practicing diabetes specialist for 15 years and 17-year career developing nutritional prescriptive products for the pharmaceutical industry has contributed to his ability to understand nutrients, how they work and why they are important.

Over the years he has acquired broad and in-depth knowledge in minerals, essential fatty acids and other nutrients, but has special expertise in Vitamin B12 and choline metabolism. He is often asked to speak at national and international venues to articulate why B12, folate and choline are so important to gene function, brain development, liver and cardiovascular health. He applies pharmaceutical standards to nutrient science and has developed a unique ability to translate complicated concepts into simple promotional messages that resonate with practitioners and consumers. He has developed dozens of innovative nutritional products, of which many are category leaders in the US. Jonathan obtained his medical degree from the University of the Witwatersrand Medical School in South Africa and did his fellowship in Endocrinology at Washington University in St. Louis, MO.

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