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X Fact
September 3, 2020
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Worried About Cognitive Decline and Is There Anything to Do About It?

We all know someone who has developed some form of cognitive decline, dementia or Alzheimer's Disease, and whom among us doesn't worry about this for ourselves or our loved ones? We also all know that there are a variety of risk factors for developing any disease, but the ones we should be concerned with are those that can be modified. Diet is a good place to start and it turns out that a well researched risk factor has been definitively tied to cognitive deterioration and that is the biomarker found in the blood called homocysteine. Homocysteine reflects the vitamin status of three B vitamins - folate, vitamin B12 and vitamin B6, and is elevated when any or all of these vitamins are deficient. In an extensive review of the literature over the past 20 years, an international panel of experts has calculated that 12% - 31% of cases or Alzheimer's Disease or dementia could be prevented by ensuring adequate intake of these three B vitamins to lower homocysteine.

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Homocysteine is an amino acid that is normally converted into other amino acids like methionine and cysteine under the influence of folate, vitamin B12, choline and vitamin B6. Homocysteine's accumulation in the blood is a good measure of deficiency of these vitamins and essential nutrients and it has been associated with elevated risk for cardiovascular disease, stroke and dementia.

Who Wrote This X Fact
Jonathan Bortz MD
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Jonathan’s background as a practicing diabetes specialist for 15 years and 17-year career developing nutritional prescriptive products for the pharmaceutical industry has contributed to his ability to understand nutrients, how they work and why they are important.

Over the years he has acquired broad and in-depth knowledge in minerals, essential fatty acids and other nutrients, but has special expertise in Vitamin B12 and choline metabolism. He is often asked to speak at national and international venues to articulate why B12, folate and choline are so important to gene function, brain development, liver and cardiovascular health. He applies pharmaceutical standards to nutrient science and has developed a unique ability to translate complicated concepts into simple promotional messages that resonate with practitioners and consumers. He has developed dozens of innovative nutritional products, of which many are category leaders in the US. Jonathan obtained his medical degree from the University of the Witwatersrand Medical School in South Africa and did his fellowship in Endocrinology at Washington University in St. Louis, MO.

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