Gene expression can be regulated without changing the DNA sequence through what is called an 'epigenetic mechanism' that frequently involves 'methylation'. The attachment of a methyl group (-CH3) to one of the DNA building blocks (cytosine) stops the gene being read. These methyl groups come from choline, betaine, folate and vitamin B12.
:the introduction of a methyl radical into a substance The methylation of metals (that is, the substitution of a metal atom for the hydrogen atom of the hydroxyl group of a methyl alcohol molecule) can result in the metal's becoming volatile.— Corale L. Brierleespecially: DNA METHYLATIONAs cells begin to specialize into adult tissues, methylation seems to inactivate genes that are no longer needed.— John Travis
Jonathan’s background as a practicing diabetes specialist for 15 years and 17-year career developing nutritional prescriptive products for the pharmaceutical industry has contributed to his ability to understand nutrients, how they work and why they are important.
Over the years he has acquired broad and in-depth knowledge in minerals, essential fatty acids and other nutrients, but has special expertise in Vitamin B12 and choline metabolism. He is often asked to speak at national and international venues to articulate why B12, folate and choline are so important to gene function, brain development, liver and cardiovascular health. He applies pharmaceutical standards to nutrient science and has developed a unique ability to translate complicated concepts into simple promotional messages that resonate with practitioners and consumers. He has developed dozens of innovative nutritional products, of which many are category leaders in the US. Jonathan obtained his medical degree from the University of the Witwatersrand Medical School in South Africa and did his fellowship in Endocrinology at Washington University in St. Louis, MO.
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